Thermally Modulated GCxGC vs 1D GC

DOCUMENT: Application | Ref: 209-066-012Download
Category: Comprehensive Chromatography, general-tofms-applications, Separation Science Mass Spectrometry

Comparing Detectability: Thermally Modulated GCxGC vs 1D GC

One of the advantages that thermally modulated GCxGC has demonstrated over 1D GC is the increase in S/N that is obtained for identical amounts of analyte on-column. This increase in S/N is attributed to compression of the chromatographic band during focusing in the thermal modulator. In a mass dependant detector, such as an MS, FID, ECD, etc., the areas of peaks with a given mass of analyte will be equal. For a given peak area, a narrower peak must have a larger amplitude and therefore a larger signal from the detector.