New! Quantification of Contact Allergens in Personal Care Products with GC and Full Mass Range TOFMS

DOCUMENT: Application | Ref: 203-821-515Download
Category: Aroma Flavour Fragrance, Life Science & Pharmaceutical, Separation Science Mass Spectrometry

Pegasus HT and the ChromaTOF deconvolution and calibration features demonstrated the potential of this technology for the investigation of contact allergens in cosmetic and personal care products. In particular, the HT’s full mass range sensitivity and speed with unparalleled deconvolution capabilities allowed to see peaks that may be hidden in a standard analysis. Ref. 203-821-515

Many cosmetic and personal care products contain fragrances and other analytes that can be allergens or irritants for some consumers. In this concern, the European Cosmetics Directive has 26 regulated contact allergens that must be reported if present in a product above certain levels. Gas chromatography (GC) paired with mass spectrometry (MS) is a well-established technique to screen for these target allergens and is commonly used, often with selected ion monitoring (SIM) detection. This application note highlights the benefits of full mass range acquisition with TOFMS. The HT’s full mass range sensitivity and speed with unparalleled deconvolution capabilities allow you to see peaks that may be hidden in a standard analysis. Calibration data for regulated analytes, as well as representative examples of product screening for quantification of these analytes were demonstrated. The need for full mass range acquisition and deconvolution even in a targeted analysis are highlighted and provide the ability to retrospectively analyze a sample to see what you are missing without repeating injection. The need for these capabilities is demonstrated through the skewed concentrations that would be determined for the target analyte, geraniol, when a matrix coelution with shared m/z is present. Ref. 203-821-515

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